With MLB 2K10 in hand I have gone through and timed different loading areas when running off the disc compared to running off the hard drive on the 360. Installing to the hard drive not only has proven to cut down on load times, in some cases significantly, but it also reduces stress to the system and the noise it produces. For MLB 2K10 the actual install process took 10:50 which is the longest install time to date and has produced marginal improvements to loading times.
Install Size- 6.4 GB
Install Time- 10:50
Loading Times
Load to Main Menu- :49 disc vs :42 hard drive (7 seconds)
Load into Game- :27 disc vs :19 hard drive (8 seconds)
Load out of Game to Main Menu- :09 disc vs :06 hard drive (3 seconds)
Load into Home Run Derby- :22 disc vs :15 hard drive (7 seconds)
Load into Positional Drill- :24 disc vs :15 hard drive (9 seconds)
Load into saved My Player- :05 disc vs :05 hard drive (No advantage)
Load into My Player Game- :19 disc vs :17 hard drive (2 seconds)
Load out of My Player Game to Menu- :19 disc vs :15 hard drive (4 seconds)
Load into saved Franchise- :06 disc vs :06 hard drive (No advantage)
As always it is recommended to install the game to the hard drive if you have the space. Though the improvements to the loading times do not appear significant they are still noticeable with the biggest benefit the 360 running quiet and cool throughout the play sessions.